代表的な発表論文・総説など

⏩ Zeng Y., Abe Y., Abe A., Takashima S., Kono M., Kagiyama, R., Komabayashi-Suzuki M., Okamoto, T.,  Ando, H., Ichihashi M., Ema M. & Mizutani K (CA).

Remodeling of Perifollicular Capillary Vessels Preferentially Crosstalk with Dermal Papilla Cells during Hair Cycling Homeostasis but Impairs while Aging.

submitted

⏩ Zeng Y., Abe Y., Saio S., Masutani T., Tabata H., Hasegawa H., Ema M., Iddamalgoda A., Ichihashi M. & Mizutani K (CA).

Spatiotemporal localization of proteoglycan constructs extracellular environment to regulate brain angiogenesis.

in preparation

⏩ Asayama S., Igarashi T., Abe Y., Akiyama K., Iwasaki A., Kubo M., Ikeda A., Okamoto T., Yagi M., Niki Y., Ando H., Ichihashi M. & Mizutani K (CA).

Rosae Multiflorae Fructus Extracts Regulate the Differentiation and Vascular Endothelial Cell-mediated Proliferation of Epidermal Keratinocytes.

in revision

⏩ Takashima S., Okamura E., Ichiyama Y., Nishi K., Shimizu A., Watanabe C., Muto M., Matsumoto S., Tsukiyama-Fujii S., Tsukiyama T., Ogita H., Nishi E., Ohji M., Sugiyama F., Takahashi S., Mizuno S., Mizutani K. & Ema M.

Null mutation of exocyst complex component 3-like does not affect vascular development in mice.

Experimental Animals 2024; 73(1): 93-100.

⏩ 今村寿子、平野才人、水谷 健一

『血管内皮細胞の挙動から導かれる多様な血管パターン形成の数理モデル』

生物物理 SEIBUTSU BUTSURI

2024;64 (3):151-154.

[in Japanese]

⏩ Ichihashi M., Tanaka M., Asai M., Iizuka T., Nagoe N., Takahashi H., Totsuka H., Fujishiro M., Yahagi S., Matsunaka H., Murakami N., Matsuo O., Ando H., Nishikata T. & Mizutani K.

Effect of an intravenous administration of adipose-tissue-derived autologous stem cells on the skin temperature of paralyzed limbs of stroke patients.

Annals of Clinical and Medical Case Reports 2023; 10: 1-9.

⏩ Ichihashi M., Tanaka M., Asai M., Iizuka T., Nagoe N., Takahashi H., Totsuka H., Fujishiro M., Yahagi S., Matsunaka H., Murakami N., Matsuo O., Ando H., Nishikata T. & Mizutani K.

A single intradermal injection of autologous adipose-tissue-derived stem cells rejuvenates aged skin and sharpens double eyelids.

Journal of Personalized Medicine 2023; 13 (7): 1162.

⏩ Watanabe C., Shibuya H., Ichiyama Y., Okamura E., Tsukiyama-Fujii S., Tsukiyama T., Matsushita J., Azami T., Kubota Y., Ohji M., Sugiyama F., Takahashi S., Mizuno S., Tamura M., Mizutani K (co-CA). & Ema M.

Essential roles of Exocyst complex component 3-like 2 on cardiovascular development in mice.

Life 2022;12 (11) 1730.

⏩ Takigawa-Imamura H., Hirano S., Watanabe C., Ohtaka-Maruyama C., Ema M. & Mizutani K (co-CA). 

Computational model exploring characteristic pattern regulation in periventricular vessels.

Life 2022;12 (12) 2069.

[プレスリリース]

⏩ 朝山紗衣、五十嵐多美、八木政幸、市橋正光、水谷 健一

『表皮の恒常性維持機構と、エイジツエキスの角化細胞分化促進作用』

FRAGRANCE JOURNAL（フレグランスジャーナル）【特集号：皮膚バリアの新知見と応用】

2022;50 (5):26-33.

[invited review article (in Japanese)]

⏩ 田上幸歩、鷹取慧、水谷 健一、剣持貴弘、鶴山竜昭，池川雅哉、吉川研一

『新規な病態計測法：組織の伸展応答パターンにおける機械学習の活用』

日本シミュレーション学会  論文誌 

2022;14 (2):133-137.

[in Japanese]

⏩ Saio S., Konishi K., Hohjoh H., Tamura Y., Masutani T., Iddamalgoda A., Ichihashi M., Hasegawa H. & Mizutani K (CA).

Extracellular environment-controlled angiogenesis, and potential application for peripheral nerve regeneration.

International Journal of Molecular Sciences 2021;22 (20):11169.

[invited review article]

⏩ Iwai R., Ishii T., Okamoto T., Fukushima Y., Ichihashi M., Sasaki Y. & Mizutani K (CA).

Matcha and its components control angiogenic potential.

Journal of Nutritional Science and Vitaminology 2021;67:119-126.

⏩ Shimizu R., Ishihara K., Kawashita E., Sago H., Yamakawa K., Mizutani K. & Akiba S.

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of Down syndrome mouse models.

Biochemical and Biophysical Research Communications 2021;535:87-92.

⏩ 河野美夕、岩崎彩夏、新井良平、阿部晃也、水谷 健一

『毛包の恒常性を維持する血管由来の微小環境と、ミノキシジルの発毛作用』

FRAGRANCE JOURNAL（フレグランスジャーナル）【特集号：皮膚における血管研究】

2021;49 (9):30-37.

[invited review article (in Japanese)]

⏩ 石原慶一、水谷 健一  

『神経-グリア-血管の連関からなる脳の細胞構築とその破綻』

YAKUGAKU-ZASSHI（薬学雑誌）2021;141:333-334.

[invited review article (in Japanese)]

⏩ 水谷 健一 

『時期特異的・領域特異的な血管化が担う、神経幹細胞・前駆細胞の調節機構』

YAKUGAKU-ZASSHI（薬学雑誌）2021;141:335-341.

[invited review article (in Japanese)]

⏩ Watanabe C., Imaizumi T., Kawai H., Suda K., Honma Y., Ichihashi M., Ema M. & Mizutani K (CA).

Aging of the vascular system and neural diseases.

Frontiers in Aging Neuroscience 2020;12:309.

[invited review article]

⏩ Leszczyński P., Śmiech M, Paranov E, Watanabe C., Mizutani K. & Taniguchi H.

Emerging roles of PRDM factors in stem cells and neuronal system: cofactor dependent regulation of PRDM3/16 and FOG1/2 (novel PRDM factor).

Cells 2020;9:2603.

[review article]

⏩ Ando H., Yoshimoto S., Tadokoro R., Kohda H., Nishikata T., Katayama B., Ozawa T., Tsuruta D., Mizutani K., Yagi M. & Ichihashi M.

Dermal fibroblasts internalize phosphatidylserine-exposed secretory melanosome clusters and apoptotic melanocytes : Possible involvement of fibroblasts in dermal pigmentation.

International Journal of Molecular Sciences 2020;21(16):5789.

⏩ Ichihashi M., Tanaka M., Iizuka T., Nagoe N., Sato Y., Takahashi H., Ueda A., Totuka H., Takanashi N., Matsuo O., Ando H. & Mizutani K.

Therapeutic effect of intravenously administered autologous adipocyte-derived stem cells on chronic stage stroke patients.

International Journal of Stem Cell Research & Therapy 2020;7(1):70.

⏩ Asayama S*., Iwasaki A*., Sahara S*., Okamoto T., Nakaoji K., Hamada K., Ichihashi M. & Mizutani K (CA).

Anti-inflammatory effect of Mallotus philippinensis bark extracts in a mouse atopic dermatitis model.

Journal of Clinical Research in Dermatology 2020; 7: 1-5.

⏩ 長谷川潤、水谷 健一 

『生体の恒常性を護る「血管化」ダイナミクス』

YAKUGAKU-ZASSHI（薬学雑誌）2020;140:507-508.

[invited review article (in Japanese)]

DOI: https://doi.org/10.1248/yakushi.19-00221-F

⏩ 水谷 健一 

『大脳皮質における神経・血管の協調的な発生機構〜VEGFシグナルの緻密な調節〜』

YAKUGAKU-ZASSHI（薬学雑誌）2020;140:521-527.

[invited review article (in Japanese)]

DOI: https://doi.org/10.1248/yakushi.19-00221-3

⏩ Suzuki-Komabayashi M*., Yamanishi E*., Watanabe C*., Okamura M., Tabata H., Iwai R., Ajioka I., Matsushita J., Kidoya H., Takakura N., Okamoto T., Kinoshita K., Ichihashi M., Nagata K., Ema M. & Mizutani K (CA).

Spatiotemporally dependent vascularization is differently utilized among neural progenitor subtypes during neocortical development.

Cell Reports 2019;29:1113-1129.

[プレスリリース]

⏩ Takashima S., Watanabe C., Ema M. &  Mizutani K (CA).

Interaction of nervous and vascular system is required for proper assembly of the neocortex.

Neurochemistry International  2019;129:104481.

[invited review article]

⏩ Iwai R., Tabata H., Inoue M., Nomura K., Okamoto T., Ichihashi M., Nagata K. & Mizutani K (CA).

A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells.

Biochemical and Biophysical Research Communications 2018;495: 388-394. 

⏩ Mizutani K (CA).

Physiological significance of the multipolar cells generated from neural progenitors for the establishment of neocortical cytoarchitecture.  

Genes to Cells 2018;23: 6-15.

[review article] 

⏩ Inoue M*., Iwai R*., Tabata H, Konno D., Suzuki-Komabayashi M., Watanabe C., Iwanari H., Mochizuki Y., Hamakubo T., Matsuzaki F., Nagata K. & Mizutani K (CA).

Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex.

Development 2017;144: 385-399. 

⏩ Matsushita J., Inagaki S., Nishie T., Sakasai T., Tanaka J., Watanabe C., Mizutani K , Miwa Y., Matsumoto K., Takara K., Naito H., Kidoya H., Takakura N., Nagai T., Takahashi T. & Ema M. Fluorescence and Bioluminescence of Angiogenesis in Flk1-Nano-lantern Transgenic Mice.

Scientific Reports 2017;20:46597.

⏩ 水谷 健一 

『神経と血管の連携がもたらす幹細胞の維持と分化の制御機構（Molecular Mechanisms of Neuro-Vascular Wiring Enabling Stem Cell Maintenance and Differentiation）』

Seikagaku （生化学　ー基礎と臨床をつなぐ血液・血管生物学ー）2017;89: 384-390.

[invited review article (in Japanese)]  

DOI: 10.14952/SEIKAGAKU.2017.890384

⏩ 水谷 健一『神経幹細胞』

Brain Science Dictionary (脳科学辞典：オンライン辞書) 

[invited review article (in Japanese)]  

DOI:10.14931/bsd.2101

⏩ 水谷 健一『神経前駆細胞』

Brain Science Dictionary (脳科学辞典：オンライン辞書) 

[invited review article (in Japanese)]  

DOI:10.14931/bsd.2102 

⏩ Inoue M*., Iwai R*., Yamanishi E*., Yamagata K., Suzuki-Komabayashi M., Komai T., Miyachi H., Kitano S., Honda A., Watanabe C., Teshima W. & Mizutani K (CA).

Deletion of Prdm8 impairs the development of the upper-layer neocortical neurons.

Genes to Cells 2015;20:758-770. 

⏩ Yamanishi E., Keejung Y., Lavinia A., Gaiano N. & Mizutani K (CA).

NF-kB signaling regulates the generation of intermediate progenitors in the developing neocortex.

Genes to Cells 2015;20:706-719. 

⏩ Nishimura Y., Shikanai M., Hoshino M., Ohshima T., Nabeshima Y., Mizutani K., Nagata K. & Kawauchi T.

Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.

Development 2014;141:3540-50.

⏩ Inoue M., Kuroda T., Honda A., Suzuki-Komabayashi M., Komai T., Shinkai Y. & Mizutani K (CA).

Prdm8 regulates the morphological transition at multipolar phase during neocortical development.

PLoS ONE 2014;9:e86356. 

⏩ Mizutani K., Yoon K., Dang L., Tokunaga A. & Gaiano N.

Differential Notch signaling distinguishes neural stem cells from intermediate progenitors.

Nature 2007;449:351-355. 

⏩ Mizutani K. & Gaiano N.

Chalk one up for ‘Nature’ during neocortical neurogenesis.

Nature Neuroscience 2006;9:717-718.

⏩ Mizutani K. & Saito T.

Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex.

Development 2005;132:1295-1304. 

⏩ Miyagi S., Saito T., Mizutani K., Masuyama N., Gotoh Y., Iwama A., Nakauchi H., Masui S., Niwa H., Nishimoto M., Muramatsu M. & Okuda A.

The Sox-2 regulatory regions display their activities in two distinct multipotent stem cells.

Molecular and Cellular Biology 2004;24:4207-4220.

⏩ Furuya M., Yasuchika K., Mizutani K., Yoshimura Y., Nakatsuji N. & Suemori H. Electroporation of cynomolgus monkey embryonic stem cells.

Genesis 2003;37:180-187

⏩ Mizutani K., Sugimoto K., Okuda T., Katsuya T., Miyata T., Tanabe T., Higaki J., Ogihara T., Yamori Y., Tsujita Y., Tago N. & Iwai N.

Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.

Hypertension Research 2002;25:135-140.

⏩ Okuda T., Sumiya T., Mizutani K., Tago N., Miyata T., Tanabe T., Kato H., Katsuya T., Higaki J., Ogihara T., Tsujita Y., Iwai N. & Kato H.

Analyses of differential gene expression in genetic hypertensive rats by microarray.

Hypertension Research 2002;25:249-255.

⏩ Mizutani K., Ikeda K., Tsuda K. & Yamori Y.

Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats.

Journal of Hypertension 2002;20:1607-1614.

⏩ Mizutani K., Ikeda K., Kawai Y. & Yamori Y.

Protective effect of resveratrol on oxidative damage in male and female stroke-prone spontaneously hypertensive rats.

Clinical and Experimental Pharmacology and Physiology 2001;28:55-59.

⏩ Mizutani K., Ikeda K. & Yamori Y.

Phytoestrogens attenuate oxidative DNA damage in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.

Journal of Hypertension 2000;18:1833-1840.

⏩ Mizutani K., Ikeda K., Ito T., Tamaki K., Nara Y. & Yamori Y.

Protective effect of inducible type nitric oxide synthase against intracellular oxidative stress caused by advanced glycation end-products in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.

Journal of Hypertension 2000;18:1071-1079.

⏩ Mizutani K., Ikeda K., Ishikado A., Kawai Y. & Yamori Y.

Antihypertensive effect of cattle bone collagen-derived peptides in ovariectomized stroke-prone spontaneously hypertensive rats.

Clinical and Experimental Pharmacology and Physiology 2000;27:416-7.

⏩ Mizutani K., Ikeda K. & Yamori Y.

Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.

Biochemical and Biophysical Research Communications 2000;21; 274:61-67.

⏩ Mizutani K., Ikeda K., Kawai Y. & Yamori Y.

Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats.

Journal of Nutritional Science and Vitaminology 2000;46:78-83.

⏩ Mizutani K., Ikeda K., Kawai Y. & Yamori Y.

Biomechanical properties and chemical composition of the aorta in genetic hypertensive rats.

Journal of Hypertension 1999;17:481-487.

⏩ Mizutani K., Ikeda K., Kawai Y. & Yamori Y.

Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP).

Journal of Nutritional Science and Vitaminology 1999;4:95-106.

⏩ Mizutani K., Ikeda K., Kawai Y. & Yamori Y.

Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

Biochemical and Biophysical Research Communications 1998;253:859-863.